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Quinine is a bitter compound that comes from the bark of the cinchona tree. The tree is most commonly found in South America, Central America, the islands of the Caribbean, and parts of the western coast of Africa. Quinine was originally developed as a medicine to fight malaria.
Quinine is an anti-malaria agent and also a potassium channel inhibitor .
What is quinine Hydrochloride used for?
It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.
What does quinine do for the body?
Quinine is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing.
What is quinine in tonic water?
Tonic water is a soft drink containing quinine, which gives it a bitter taste. Quinine is a common treatment for malaria. Some people believe that it can also help with leg cramps and restless legs syndrome. Quinine comes from the bark of the cinchona tree.
Is quinine poisonous?
Quinine, termed a “general protoplasmic poison” is toxic to many bacteria, yeasts, and trypanosomes, as well as to malarial plasmodia. Quinine has local anesthetic action but also is an irritant. The irritant effects may be responsible in part for the nausea associated with its clinical use.
Does quinine cause weight gain?
Body weight and fat mass gains are significantly diminished by quinine. Fat mass gain is significantly lower in Trpm5 KO mice. There is a trend for interaction diet genotype for body weight, were the effect of quinine is larger in the weight than in the background.